Gennaro was the son of Francesco DelGuzzo but his mother is unknown. The date and place of his birth have not been found.
His wife was Angela Severini. They were married, but the date and place have not been found. Their five known children were Angelo Antonio Gennaro (1782-?), Angela Rosa (1784-1843), Giamberardino (1789-1877), Isabella (1794-1857) and Feliceantonio (1800-1880).